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Part 2
Fat-Burning Capability
To understand how HCA both inhibits us from producing fat and helps us burn fat, we should consider a simplified explanation of what happens when we eat too many carbohydrates. The following numbers and letters correspond to those on the illustration.
1. When we over consume carbohydrates, we have an over abundance of a substance known as acetyl coenzyme A (acetyl CoA).
2. Acetyl CoA cannot pass out of the mitochondrion, whiich is the cell's "energy plant." Because of this, the body transforms acetyl CoA into something called citrate. Citrate does pass out of the mitochondrion and into the cell cytosol, which is the fluid section of the cell.
3. Here, the enzyme ATP citrate lyase separates the citrate into two components, acetyl CoA and oxaloacetate.
4.+ 5. The acetyl CoA is then converted into a substance known as malonyl coenzyme A (malonyl CoA). Malonyl CoA is the "base" from which fatty acids (and thus fat) and cholesterol are formed from carbohydrates. You can see that if malonyl CoA is formed, the body is able to produce fat (and cholesterol).
6. Malonyl CoA also blocks the activity of the enzyme carnitine acyltransferase. This enzyme transports existing fats back into the mitrochondrion where they can be burned. When malonyl CoA blocks its activity, it is harder to burn fat (and lose weight). We could say that when the body creates fat (due to malonyl CoA), it does not burn fat (because malonyl CoA does not let fat be transported to the mitochondrion).
A. Research indicates that HCA may work by blocking ATP citrate lyase from separating Acetyl CoA from citrate. If there is no acetyl CoA, it cannot be converted into malonyl CoA. If there is no malonyl CoA, fats and cholesterol cannot be easily created.
B. Just as importantly, the absence of malonyl CoA means that carnitine acyltranferase can transport existing fat into the mitochondrion where fats can be more easily burned. You might say that if the body does not create fat (there is no malonyl CoA to form fatty acids), it can burn fat (there is no malonyl CoA to prevent fat from being transported to the mitochondrion.
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AIM Metabolite contains HCA, Gymnema Sylvestre and Chromium Picolinate. Click on the bottle to learn more! Retail: $26.50 |
The article "Fat-Burning Capability" is reproduced with the permission of AIM International
© 1997 - 1999 by AIM USA, Partner's Magazine - March '99.
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